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KMID : 1143220180610060662
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Obstetrics & Gynecology Science
2018 Volume.61 No. 6 p.662 ~ p.668
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Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
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So Kyeong-A
Kim Seon-Ah
Lee Yoo-Kyung
Lee In-Ho
Lee Ki-Heon
Rhee Jee-Eun
Kee Mee-Kyung
Cho Chi-Heum
Hong Sung-Ran
Hwang Chang-Sun
Jeong Mi-Seon
Kim Ki-Tae
Ki Mo-Ran
Hur Soo-Young
Park Jong-Sup
Kim Tae-Jin
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Abstract
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Objective: This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL).
Methods: We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20?60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing.
Results: Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08?2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P<0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01?17.00).
Conclusion: The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression.
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KEYWORD
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Papillomaviridae, Smoking, Epidemiology
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